Figure 3. Altered drug-induced endovesiculation of erythrocytes from neuroacanthocytosis patients.

ChAc, McLeod and PKAN+, as well as control erythrocytes were subjected to drug-induced endovesiculation using 1.5 mM primaquine, 0.4 mM chlorpromazine and 0.75 mM imipramine. The uptake of FITC-labeled dextran was determined by flow cytometry. Overlays of representative histograms of patients (red) and respective control samples (blue) clearly indicate an impaired ability of the patient’s erythrocytes to form endovesicles.