Table 5. Predictive values of rifampicin resistance in a hypothetic cohort of 1000 participants.
Index Test |
3% Rifampicin Resistance
|
15% Rifampicin Resistance
|
30% Rifampicin Resistance
|
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
PPV | NPV | FP | FN | PPV | NPV | FP | FN | PPV | NPV | FP | FN | |
(95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | |||||||
INNO LiPA | 71.0% | 99.8% | 12 | 2 | 93.3% | 99.0% | 11 | 9 | 97.1 | 97.5% | 9 | 18 |
(31.1, 85.3) | (99.0, 99.9) | (72.0, 97.1) | (94.6, 99.6) | (86.2, 98.8) | (87.9, 98.9) | |||||||
MTBDRplus | 59.3% | 99.9% | 21 | 1 | 89.2% | 99.3% | 18 | 6 | 95.3% | 98.3% | 15 | 12 |
(37.7, 69.5) | (99.7, 99.9) | (77.5, 92.9) | (98.3, 99.5) | (89.3, 96.9) | (95.9, 98.9) | |||||||
MODS | 79.8% | 99.9% | 8 | 1 | 95.8% | 99.7% | 7 | 3 | 98.2% | 99.2% | 5 | 6 |
(35.5, 91.5) | (99.6, 99.9) | (75.9, 98.4) | (97.6, 99.9) | (88.4, 99.3) | (94.5 99.7) | |||||||
NRA | 93.0% | 99.9% | 2 | 1 | 98.7% | 99.6% | 2 | 3 | 99.5% | 99.0% | 1 | 7 |
(73.0, 96.7) | (99.6, 99.9) | (93.9, 99.4) | (98.0, 99.8) | (97.4, 99.8) | (95.3, 99.6) | |||||||
CRI | 93.2% | 99.9% | 2 | 1 | 98.7% | 99.8% | 2 | 2 | 99.5% | 99.5% | 2 | 4 |
(74.9, 96.8) | (99.8, 99.9) | (94.4, 99.4) | (99.2, 99.9) | (97.6, 99.8) | (98.1, 99.8) |
CI= Confidence Interval PPV=positive predictive value, NPV=negative predictive value, FP= number of false positive index test results for a cohort of 1000 patients, FN= number of false negative index test results for a cohort of 1000 patient