Table 1. Effect of Levetiracetam (LEV, 500 mg/kg i.p.) on lithium-pilocarpine (Li-PIL) -induced seizures in rats.
Groups | Median seizure stage (minimum – maximum) | Stage 3 seizure latency (min) | Stage 3 to 5 seizure incidence (%) |
---|---|---|---|
Li-PIL | 5 (3-5)* | 5.167±0.207a | 100* |
LEV500 | 1 (0-3)@ | 26.958±2.069b | 16.7*,@ |
In the seizure stage, values are median of 12 rats; statistical comparisons were carried out using Kruskal–Wallis test (nonparametric ANOVA) followed by Dunn’s multiple comparisons test. In the parametric analysis (stage 3-5 seizure latency), values are means of 12 animals ± S.E.M.; statistical comparisons were carried out using one-way ANOVA followed by Student–Newman–Keuls multiple comparisons test. Stage 3-5 seizure incidence (12 animals) was compared using Fisher’s exact probability test as compared to control (*) and Li-PIL (@ groups, P<0.05.