. 2013 Oct 3;8(10):e76448. doi: 10.1371/journal.pone.0076448

Table 5. Incidence density and risk of cardiovascular disease for gallstone and non-gallstone disease groups stratified by age and sex.

	No gallstone			Gallstone
	CVD		Incidence ^a	CVD		Incidence ^a	Crude HR (95% CI)^b	Adjusted HR (95% CI)
	No	Yes		No	Yes
Gender
Female	14203	1493	17.3	3414	510	25.3	1.47 (1.33-1.63)***	1.35 (1.22-1.50)*** ^c
Male	10963	1265	19.0	2632	425	27.0	1.43 (1.28-1.59)***	1.29 (1.15-1.44)*** ^c
Age (in years)
18-40	8352	228	4.7	2057	88	7.6	1.64 (1.28-2.10)***	1.42 (1.09-1.84)** ^d
41-60	12278	1273	17.2	2923	464	26.7	1.57 (1.41-1.75)***	1.35 (1.21-1.51) *** ^d
>60	4536	1257	42.4	1066	383	55.2	1.32 (1.17-1.47)***	1.24 (1.10-1.39) *** ^d

Abbreviation: CVD, cardiovascular disease; CI, confidence interval; HR, hazard ratio.

Per 1000 person years.

Within 6 years of follow up.

Adjusted for age, peripheral vascular disease, chronic obstructive pulmonary disease, diabetes mellitus, hyperlipidemia, hypertension, alcoholism, chronic liver disease, and anemia.

Adjusted for age, gender, peripheral vascular disease, chronic obstructive pulmonary disease, diabetes mellitus, hyperlipidemia, hypertension, alcoholism, chronic liver disease, and anemia.

* P<0.05; **P<0.01; ***P<0.001