Table 1. HO-1 dependence of protection of THI-56 against organ injury in CLP-induced septic mice.
Treatment | ALT (U/L) | AST (U/L) | BUN (U/L) | Creatinine (mg/dL) |
Sham | 73.3±23.8 | 320.1±100.9 | 18.5±0.4 | 0.38±0.35 |
CLP | 350.9±145.6* | 945.5±204.2** | 37.1±2.3** | 1.66±0.02* |
CLP+THI56 (5 mg/kg) | 298.6±106.7 | 803.2±309.7 | 23.8±3.2# | 1.35±0.04# |
CLP+THI56 (10 mg/kg) | 274.1±7.4# | 855.5±148.7 | 21.3±0.7## | 0.83±0.14## |
CLP+THI56 (5 mg/kg)+ZnPP (10 mg/kg) | 369.0±16.5 | 865.1±150.9 | 37.6±3.4$ | 1.87±0.50$ |
CLP+THI56 (10 mg/kg)+ZnPP (10 mg/kg) | 426.0±48.0† | 1045.5±114.5 | 34.3±6.3† | 1.21±0.41† |
Mice were intraperitoneally administered 5 mg/kg or 10 mg/kg THI56 2 h prior to CLP. Twenty four h after CLP, blood was withdrawn under anesthesia by heart puncture from each group of animals. The results are presented as mean ± SEM (n = 3–6). Significantly different (*P<0.05, **P<0.01) from sham. Significantly different (# P<0.05, ##P<0.01) from CLP. Significantly different ($ P<0.05) from CLP+THI56 (5 mg/kg). Significantly different († P<0.05) from CLP+THI56 (10 mg/kg).