. 2013 Oct 3;8(10):e76293. doi: 10.1371/journal.pone.0076293

Table 1. HO-1 dependence of protection of THI-56 against organ injury in CLP-induced septic mice.

Treatment	ALT (U/L)	AST (U/L)	BUN (U/L)	Creatinine (mg/dL)
Sham	73.3±23.8	320.1±100.9	18.5±0.4	0.38±0.35
CLP	350.9±145.6*	945.5±204.2**	37.1±2.3**	1.66±0.02*
CLP+THI56 (5 mg/kg)	298.6±106.7	803.2±309.7	23.8±3.2^#	1.35±0.04^#
CLP+THI56 (10 mg/kg)	274.1±7.4^#	855.5±148.7	21.3±0.7^##	0.83±0.14^##
CLP+THI56 (5 mg/kg)+ZnPP (10 mg/kg)	369.0±16.5	865.1±150.9	37.6±3.4^$	1.87±0.50^$
CLP+THI56 (10 mg/kg)+ZnPP (10 mg/kg)	426.0±48.0^†	1045.5±114.5	34.3±6.3^†	1.21±0.41^†

Mice were intraperitoneally administered 5 mg/kg or 10 mg/kg THI56 2 h prior to CLP. Twenty four h after CLP, blood was withdrawn under anesthesia by heart puncture from each group of animals. The results are presented as mean ± SEM (n = 3–6). Significantly different (*P<0.05, **P<0.01) from sham. Significantly different (^# P<0.05, ^##P<0.01) from CLP. Significantly different (^$ P<0.05) from CLP+THI56 (5 mg/kg). Significantly different (^† P<0.05) from CLP+THI56 (10 mg/kg).