Table 5. Topological Characteristics of the protein-protein interaction network of age-correlated genes.
Topological Characteristics in Protein-Protein Interaction Network | ||||||||||||
Degree | Betweenness Centrality | Closeness Centrality | Clustering Coefficient | |||||||||
Young | Middle-aged | Old | Young | Middle-aged | Old | Young | Middle-aged | Old | Young | Middle-aged | Old | |
BA10 | 13.083 | 11.894 | 12.645 | 6.74E-04 | 6.14E-04 | 7.05E-04 | 0.250 | 0.249 | 0.250 | 0.097 | 0.103 | 0.100 |
Z-score | 10.412 | 8.761 | 9.009 | 6.787 | 5.874 | 6.968 | 9.863 | 8.798 | 8.827 | −1.212 | −0.322 | −0.750 |
BA9 | 10.237 | 10.774 | 10.844 | 5.15E-04 | 5.45E-04 | 5.30E-04 | 0.247 | 0.247 | 0.250 | 0.094 | 0.101 | 0.094 |
Z-score | 3.665 | 7.087 | 5.806 | 2.669 | 5.103 | 3.720 | 4.804 | 8.124 | 8.546 | −1.318 | −0.726 | −1.595 |
BA47 | 11.254 | 10.516 | 8.573 | 6.29E-04 | 5.29E-04 | 3.78E-04 | 0.247 | 0.246 | 0.244 | 0.102 | 0.102 | 0.087 |
Z -score | 5.635 | 6.495 | 0.940 | 4.868 | 4.593 | 0.453 | 5.130 | 7.212 | 2.705 | −0.406 | −0.612 | −2.074 |
For each of the three brain regions age-correlated genes divided into three age groups: young (<40 years old), middle-age (between 40 and 59 years old) and old (between 60 and 79 years old).