Table 1. Stratified descriptive statistics by gender and smoking for the discovery cohort (Genetic Epidemiology Network of Arteriopathy Study, GENOA) and the replication cohort (Framingham Heart Study).
| GENOA | ||||||
| Males (N = 376) | Females (N = 539) | |||||
| Smoker (N = 219) | Non-Smoker (N = 157) | P value | Smoker (N = 207) | Non-Smoker (N = 332) | P value | |
| CAC>100 n(%)a | 103 (69.1) | 64 (54.7) | 0.228 | 46 (30.9) | 53 (45.3) | 0.068 |
| CAC≤100 n(%) | 116 (41.9) | 93 (25.0) | 161 (58.1) | 279 (75.0) | ||
| CAC score | 340.8 | 270.5 | 150.1 | 83.5 | ||
| Log (CAC +1)b | 3.82±2.6 | 3.55±2.5 | 0.30 | 2.67±2.5 | 1.96±2.2 | 0.05 |
| Age (years) | 58.7±9.7 | 58.0±10.9 | 0.530 | 56.6±9.4 | 58.7±10.5 | 0.197 |
| LDL-C (mg/dL) | 113.3±27.7 | 122.8±31.8 | 0.002 | 116.3±30.5 | 115.9±32.0 | 0.868 |
| BMI (kg/m2) | 30.8±5.1 | 30.7±5.1 | 0.829 | 30.5±7.6 | 30.8±6.6 | 0.685 |
| Pulse Pressure | 54.2±14.1 | 53.2±14.9 | 0.536 | 56.0±14.4 | 59.7±16.4 | 0.008 |
| Diabetes n(%) | 41 (18.7) | 19 (12.1) | 0.084 | 24 (11.6) | 39 (11.8) | 0.957 |
| Hypertensive Meds n(%) | 140 (63.9) | 102 (65.0) | 0.835 | 136 (65.7) | 225 (67.8) | 0.619 |
| Lipid Lowering Meds n(%) | 77 (35.2) | 43 (27.4) | 0.111 | 43 (20.8) | 67 (20.2) | 0.868 |
CAC, coronary artery calcification; LDL-C, Low Density Lipoprotein-Cholesterol; BMI, body mass index.
a
For categorical variables, the number and percent are presented (Chi-square P-values).
b
For continuous variables, the mean and standard deviation are presented (t-test P-values).