Table 2. Significant and suggestive QTL identified by genome-wide scan of F2 mice.
| Trait | QTLa | Chr | Peak cM | 95% CI | LODb | Nearest marker | Sex | High Strain; Inheritance |
|---|---|---|---|---|---|---|---|---|
| HDL cholesterol | Cq1c | 1 | 74.7 | 70.6−81.6 | 8.9 | rs13476229 | MF | KK, Add |
| − | 2 | 36.2 | 21.2−51.2 | 3.1 | rs3718711 | M | I, Add | |
| − | 3 | 19.2 | 17.2−38.2 | 3.4 | rs6324747 | F | I, Add | |
| − | 4 | 75.1 | 60.1−88.6 | 3.1 | UT_4_132.137715 | F | KK, Add | |
| − | 6 | 24.8 | 9.8−44.8 | 2.9 | rs6355719 | MF | KK, Dom | |
| Hdlq84 | X | 38.4 | 33.4−40.4 | 9.3 | rs13483831 | MF, M | KK, Add | |
| Non-HDL cholesterol | Nhdlq13 | 1 | 67.7 | 56.7−78.7 | 3.2 | rs6185344 | MF, F | KK, Rec |
| Nhdlq14 | 3 | 32.4 | 29.2−35.2 | 4.5 | rs6198234 | MF | Het, UDom | |
| − | 5 | 42.8 | 23.8−55.8 | 2.3 | rs3667334 | F | KK, Dom | |
| − | 7 | 64.0 | 50.0−79.0 | 2.3 | rs13479455 | F | I, Add | |
| − | 14 | 41.9 | 19.9−54.9 | 2.2 | rs6156908 | F | KK, Add | |
| − | X | 38.3 | 18.4−61.4 | 3.3 | rs13483831 | MF, F | KK, Add |
QTL, quantitative trait loci; CI, confidence interval; LOD, logarithm of the odds ratio; HDL, high-density lipoprotein.
a
QTL were named if they were significant or if they were suggestive but confirmed QTL reported previously.
b
Significant LOD scores were determined by 1000 permutations for the autosomes and 16,803 permutations for Chr X and are indicated in bold.
c
Apoa2 is the likely causative gene.