Figure 2. Comparison of Foxp3 mRNA expression and circulating adipocytokines and inflammatory mediators in MS patients in term of the clinical course of disease.

In parallel with disease progression in patients with MS, the level of inflammatory markers as well as adipocytokines including resistin and leptin decreased and the expression of FoxP3 and circulating level of visfatin increased.

TNF-α: tumor necrosis factor-alpha; IL-1β: interleukin-1 beta; hs-CRP: high sensitivity C-reactive protein; Foxp3: forkhead box P3.