Table 3. Association of non-synonymous variants with the HNPK phenotype.
Genotype | Labrador Retriever cases | Labrador Retriever non-affected carriersa | Labrador Retriever controls | Dogs from other breeds |
ITGA:c.363A>G | ||||
A/A | - | - | 1 | 2 |
A/G | - | 1 | 2 | 2 |
G/G | 15 | 3 | 5 | 10 |
RPP38:c.381A>G | ||||
A/A | - | - | 216 | 40 |
A/G | - | 4 | 65 | 21 |
G/G | 16 | - | 1 | 16 |
SUV39H2:c.972T>G | ||||
T/T | - | - | 327 | 139 |
T/G | - | 4 | 48 | - |
G/G | 26 | - | - | - |
Parents of affected dogs were classified as obligate carriers.