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. Author manuscript; available in PMC: 2014 Oct 15.
Published in final edited form as: Bioorg Med Chem. 2013 Jun 1;21(20):6217–6223. doi: 10.1016/j.bmc.2013.05.037

Scheme 1. Conjugation of cRGD peptides with a thiol modified 2’-O-Me phosphorothioate oligonucleotide.

Scheme 1

The 5’ disulfide splice switching oligonucleotide is reduced and then conjugated to a maleimide terminated cyclic RGD peptide, as described in the text.