Table 2.
Intensity of immunolabeling of lumbar spinal cord gray matter in sections from SOD1G93A transgenic mice (+) and nontransgenic littermates (−)
| Mouse number | Age (days) | Sex | B.W. (g) | G93A mutant | Symptoms | Clusterin | αB-crystallin | GFAP | Iba1 |
|---|---|---|---|---|---|---|---|---|---|
| Early presymptomatic age | |||||||||
| 274/6 | 45 | M | 24 | − | − | − | − | ++ | + |
| 274/7 | 45 | M | 22 | − | − | − | − | ++ | − |
| 274/5 | 45 | M | 22 | + | − | − | − | ++ | +++ |
| 274/4 | 45 | M | 20 | + | − | − | − | ++ | + |
| 274/8 | 45 | M | 24 | + | − | − | − | ++ | + |
| Late presymptomatic age | |||||||||
| 273/3 | 79 | F | 18 | − | − | − | − | ++ | + |
| 273/4 | 79 | M | 31 | − | − | − | − | ++ | + |
| 273/5 | 79 | M | 30 | − | − | − | − | ++ | − |
| 273/1 | 79 | F | 20 | + | − | − | − | +++ | ++ |
| 273/2 | 79 | F | 22 | + | − | − | − | ++++ | + |
| 273/6 | 79 | M | 26 | + | − | − | − | +++ | + |
| Overtly symptomatic age | |||||||||
| 267/3 | 141 | M | 32 | − | − | − | − | ++ | + |
| 256/3 | 191 | F | 19 | − | − | − | − | ++ | − |
| 262/5 | 179 | M | 44 | − | − | − | − | +++ | − |
| 260/4 | 164 | M | 32 | − | − | − | − | ++ | − |
| 256/4 | 191 | F | 22 | + | − | − | + | ++++ | +++ |
| 267/4 | 141 | M | 23 | + | y | ++ | ++ | +++++ | ++++ |
| 260/3 | 164 | F | 21 | + | y | ++ | +++ | +++++ | +++++ |
| 262/4 | 179 | M | 34 | + | y | ++ | ++ | +++++ | ++ |
B.W. body weight, + very weak, ++ weak, +++ medium, ++++ strong, +++++ very strong immunoreaction