Table 5.
Distribution of genotype frequencies of HSPA1A G190C, HSPA1B A1267G, and HSPA1L T2437C polymorphisms in controls and patients with different cataract subtypes
| Genotype | Control n (%) | Cataract subtypes | |||
|---|---|---|---|---|---|
| Cortical n (%) | Nuclear n (%) | PSCC n (%) | Mixed n (%) | ||
| n = 121 | n = 109 | n = 59 | n = 126 | ||
| HSPA1A G190C | |||||
| G/G | 223 (57.8) | 61 (50.4) | 61 (56.0) | 34 (57.6) | 70 (55.6) |
| G/C | 139 (36.0) | 50 (41.3) | 38 (34.9) | 17 (28.8) | 45 (35.7) |
| C/C | 24 (6.2) | 10 (8.3) | 10 (9.1) | 8 (13.6) | 11 (8.7) |
| HSPA1B A1267G | |||||
| A/A | 109 (28.2) | 20 (16.5)* | 26 (23.9) | 13 (22.1) | 27 (21.4) |
| A/G | 175 (45.3) | 59 (48.8) | 54 (49.5) | 30 (50.8) | 66 (52.4) |
| G/G | 102 (26.5) | 42 (34.7) | 29 (26.6) | 16 (27.1) | 33 (26.2) |
| HSPA1L T2437C | |||||
| T/T | 163 (42.2) | 49 (40.5) | 42 (38.5) | 25 (42.4) | 47 (37.3) |
| T/C | 175 (45.4) | 59 (48.8) | 54 (49.5) | 26 (44.1) | 56 (44.4) |
| C/C | 48 (12.4) | 13 (10.7) | 13 (12.0) | 8 (13.5) | 23 (18.3) |
PSCC posterior subcapsular cataract
*p = 0.012; OR, 0.503; 95 % CI, 0.297–0.854