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. 2013 Aug 16;288(40):28447–28456. doi: 10.1074/jbc.M113.499368

FIGURE 1.

FIGURE 1.

Conversion of 2,4,5-trichlorophenoxy acetic acid to 2-hydroxybenzoquinone. TftAB converts 2,4,5-trichlorophenoxy acetic acid to 2,4,5-TCP. TftCD converts 2,4,5-TCP to 2,5-dichlorobenzoquinone (not shown), which is reduced to 2,5-DCHQ. TftD further dechlorinates 2,5-DCHQ to 5-chloro-2-hydroxybenzoquinone (not shown), which is reduced to 5-chloro-2-hydroxyhydroquinone, the substrate of TftG. TftG catalyzes the dehydrochlorination of 5-chloro-2-hydroxyhydroquinone to the product 2-hydroxybenzoquinone, which subsequently enters the TCA cycle after several previously established enzymatic steps. This figure was produced using ChemDraw (version 12.0.2).