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. 2013 Aug 8;288(40):28733–28742. doi: 10.1074/jbc.M113.457119

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 9. — Inhibition by warfarin of VKOR activity in liver of male OFA Sprague-Dawley rats. VKOR activity versus vit K₁>O (from 0 to 200 μm) was determined in the presence of four different concentrations of warfarin incubated with rat liver microsomes. Each data point represents the mean ± S.D. (error bars) of two determinations. The experimental results were fitted by nonlinear regression using the noncompetitive inhibition model, and the K_m and K_i parameters were determined for recombinant rat VKORC1 (i.e. 19.6 and 0.6 μm).