TABLE 1.
Up-regulated genes in Caki-1 cell treated with IL-4
The gene expression profile of Caki-1 cells treated with IL-4 (10 ng/ml) for 24 h was assessed by microarray analysis using the Affymetrix GeneChip Human Gene 2.0 ST Array, which contains more than 48,000 human genes. This table shows some of the genes up-regulated more than 1.8-fold in IL-4-treated cells compared to untreated control cells.
| Category | Accession number | Gene name | Description | -Fold |
|---|---|---|---|---|
| Adhesion molecules | NM_001078 | VCAM1 | Vascular cell adhesion molecule 1 | 1.94 |
| NM_003637 | ITGA10 | Integrin, α10 | 1.82 | |
| Growth factors and receptors | NM_001552 | IGFBP4 | Insulin-like growth factor binding protein 4 | 2.82 |
| ENST00000230990 | HBEGF | Heparin-binding EGF-like growth factor | 2.35 | |
| Cytokines, chemokines, andreceptors | ENST00000394905 | CCL26 | Chemokine (C-C motif) ligand 26 | 7.91 |
| ENST00000371936 | IL-13RA2 | Interleukin 13 receptor, α2 | 3.85 | |
| ENST00000303115 | IL-7R | Interleukin 7 receptor | 2.89 | |
| ENST00000293272 | CCL5 | Chemokine (C-C motif) ligand 5 | 2.64 | |
| ENST00000296861 | TNFRSF21 | Tumor necrosis factor receptor superfamily, member 21 | 2.34 | |
| NM_152456 | IL-34 | Interleukin 34 | 2.28 | |
| ENST00000404625 | IL-6 | Interleukin6 (interferon, β2) | 1.84 | |
| Cell cycle | NM_001220778 | CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1.81 |
| Transcription | NM_001206616 | EHF | Ets homologous factor | 4.39 |
| NM_001717 | BNC1 | Basonuclin 1 | 3.44 | |
| ENST00000407775 | ZFPM2 | Zinc finger protein, multitype 2 | 3.36 | |
| Extracellular matrix | ENST00000404816 | LTBP1 | Latent transforming growth factor β-binding protein 1 | 8.41 |
| NM_198391 | FLRT3 | Fibronectin leucine rich transmembrane protein 3 | 6.54 | |
| ENST00000380548 | ADAMTSL1 | ADAMTS-like 1 | 3.09 | |
| NM_001039348 | EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | 3.00 | |
| NM_002317 | LOX | Lysyl oxidase | 2.27 | |
| NM_001848 | COL6A1 | Collagen, type VI, α1 | 2.19 | |
| ENST00000261037 | COL8A1 | Collagen, type VIII, α1 | 2.03 | |
| NM_001849 | COL6A2 | Collagen, type VI, α2 | 1.92 | |
| Others | NM_006919 | SERPINB3 | Serpin peptidase inhibitor, clade B (ovalbumin), member 3 | 34.85 |
| NM_013324 | CISH | Cytokine inducible SH2-containing protein | 5.92 | |
| NM_033256 | PPP1R14A | Protein phosphatase 1, regulatory (inhibitor) subunit 14A | 3.97 | |
| NM_003745 | SOCS1 | Suppressor of cytokine signaling 1 | 3.31 | |
| NM_000927 | ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 3.21 | |
| NM_001004343 | MAP1LC3C | Microtubule-associated protein 1 light chain 3 gamma | 3.10 | |
| NM_001102445 | RGS4 | Regulator of G-protein signaling 4 | 2.59 | |
| ENST00000296861 | TNFRSF21 | Tumor necrosis factor receptor superfamily, member 21 | 2.34 |