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Differential binding capacities of loop-specific monoclonal antibodies to the gp41 loop domain and its analogues
| MAb | Epitope | Locationa | Antibody bindingb |
||||
|---|---|---|---|---|---|---|---|
| L27 WT | L27 K601A | L27 L602A | L42 WT | N27 | |||
| T32 | WGCSGKLICTTAVPWNA | 596–612 | + | − | − | + | − |
| 240-D | IWG | 595–597 | + | + | + | + | − |
| 246-D | LLGI | 592–595 | + | − | + | + | − |
a Residue numbers correspond to the HIV-1 HXB2 gp160 variant.
b + represents antibody binding, and − represents no binding.
