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. 2013 Aug 19;288(40):29160–29169. doi: 10.1074/jbc.M113.464107

FIGURE 4.

FIGURE 4.

PKC inhibition negatively regulates Syk downstream targets, LAT and PLCγ2. Human platelets were treated as in Fig. 1Bi. A and C, analysis was performed of phosphorylation of LAT phosphotyrosine 191 and total LAT (A) or PLCγ2 phosphotyrosine 759 and total PLCγ2 (C). B and D, quantitation of the blots with mean ± S.E. (error bars) of relative Syk phosphorylation for Cvx in untreated (●) and GFX-treated (▴) platelets was plotted against time, and Student's t test was performed (p < 0.05, untreated versus GFX-treated platelets). Blots are representative of at least three independent experiments.