Table 1.

Summary of time-lapse studies evaluating various morphokinetic events and timings and correlation to embryonic aneuploidy

Timing endpoint assessment	Biopsy type	Diagnosis approach	Imaging system	Aneuploidy correlation	Reference
Prolonged duration of 1st cytokineses, time between 1st and 2nd mitosis	Day 2	aCGH	Eeva™	Yes	[15]
1st division, 2nd division, appearance of 4th blastomere, 3rd division	Trophectoderm	aCGH	Embryoscope®	No	[65]
PN appearance, PN disappearance, cleaving timing, compaction, cavitation	Trophectoderm	qPCR	Embryoscope®	No	[68]
1st cytokinesis, 2nd mitotic division, synchronicity of 3rd/4th cells	Polar body & Trophectoderm	aCGH	Eeva™	Yes	[29]
Cleavage times until the 8cell stage, 2–3cell division, 3–4cell division,	Day 3	FISH	Embryoscope®	No	[12]
Shorter 5 to 8– cell division (3rd synchrongy division)	Day 3	FISH	Embryoscope®	Yes	[12]
"Optimal" timings of 2nd synchrony, time to 5-cell, 2nd cell cycle	Day 3	FISH or aCGH	Embryoscope®	No	[10]
Duration 1st and 2nd mitosis synchrony 2nd & 3rd cell cycle, blastulation duration, 2cell multinucleation	Trophectoderm	aCGH or SNP array	Embryoscope®	No	[13]
Delayed compaction, cavitation, full blastocyst formation	Trophectoderm	aCGH or SNP array	Embryoscope®	Yes	[14]
Early compaction	Trophectoderm	aCGH	Embryoscope®	Yes	[52]
Syngamy, cavitation	Trophectoderm	aCGH	Embryoscope®	No	[52]
First sign of fragmentation	Trophectoderm	aCGH	Embryoscope®	No	[56]