Table 3.

Histomorphometric Findings at the end of 12 weeks of follow-up or therapy in normal dogs, in untreated control heart failure (HF) dogs and in heart failure dogs treated with Capadenoson (CAP)

	VFRF (%)	VFIF (%)	CD (cap/mm2)	ODD (μm)	MCSA (μm2)
Normal	0.0	3.7±0.07	2609±79.5	8.9±0.17	410±10.0
HF-Control	12.3±1.34*	15.2±0.63*	1775±72.9*	14.5±0.44*	663±12.3*
HF-Capadenoson	10.8±0.83	11.3±1.31†	2077±46.1†	11.5±0.51†	548±24.4†

Data are shown as Mean ± SEM. VFIF = volume fraction of interstitial fibrosis; VFRF = volume fraction of replacement fibrosis; CD = capillary density; ODD = oxygen diffusion distance; MCSA = myocyte cross-sectional area;

^*p<0.05 vs. Normal,

^†p<0.05 vs. HF-Control.