Table I.
Characteristics of patients with del(13q) CLL, overall and by IGHV mutation percentage.
| All patients (n = 79) |
IGHV <2% (n = 38) |
IGHV ≥2% (n = 41) |
p-Value* | |
|---|---|---|---|---|
| Age at diagnosis, median (range) | 57 (27, 81) | 58 (27, 81) | 56 (31, 71) | 0.58 |
| Stage at diagnosis, n (%) | ||||
| Rai 0 | 30 (42) | 14 (39) | 16 (46) | 0.23 |
| Rai 1 | 26 (37) | 15 (42) | 11 (31) | |
| Rai 2 | 11 (15) | 4 (11) | 7 (20) | |
| Rai 3 | 3 (4) | 3 (8) | 0 (0) | |
| Rai 4 | 0 (0) | 0 (0) | 0 (0) | |
| Richter | 1 (1) | 0 (0) | 1 (3) | |
| Unknown | 8 | 2 | 6 | |
| Time from diagnosis to initial JHU consultation (years), median (range) |
0.4 (0, 16.1) | 0.6 (0, 7.6) | 0.3 (0, 16.1) | 0.94 |
| Stage at initial JHU consultation, n (%) | ||||
| Rai 0 | 28 (36) | 12 (32) | 16 (39) | 0.18 |
| Rai 1 | 25 (32) | 13 (35) | 12 (29) | |
| Rai 2 | 11 (14) | 3 (8) | 8 (20) | |
| Rai 3 | 7 (9) | 6 (16) | 1 (2) | |
| Rai 4 | 6 (8) | 3 (8) | 3 (8) | |
| Richter | 0 (0) | 0 (0) | 1 (2) | |
| Unknown | 1 | 1 | 0 | |
| Received treatment prior to JHU consultation | ||||
| No | 62 (78) | 29 (76) | 33 (80) | 0.79 |
| Yes | 17 (22) | 9 (24) | 8 (20) | |
| Time from diagnosis to FISH (years), median (range) |
1.6 (0, 21.4) | 1.4 (0, 10.2) | 2.2 (0, 21.4) | 0.41 |
| Sole del(13q), n (%) | ||||
| No | 32 (41) | 25 (66) | 7 (17) | < 0.001 |
| Yes | 47 (59) | 13 (34) | 34 (83) | |
| Trisomy 12, n (%) | ||||
| No | 77 (97) | 37 (97) | 40 (98) | >0.99 |
| Yes | 2 (3) | 1 (3) | 1 (2) | |
| del(6q), n (%) | ||||
| No | 74 (94) | 34 (89) | 41 (100) | >0.99 |
| Yes | 4 (5) | 4 (11) | 0 (0) | |
| del(11q), n (%) | ||||
| No | 61 (77) | 23 (61) | 37 (90) | < 0.001 |
| Yes | 18 (23) | 15 (39) | 4 (10) | |
| del(17p), n (%) | ||||
| No | 70 (89) | 30 (79) | 40 (98) | 0.01 |
| Yes | 9 (11) | 8 (21) | 1 (2) | |
| del(11q) or del(17p), n (%) | ||||
| No | 52 (66) | 15 (39) | 36 (88) | < 0.001 |
| Yes | 27 (34) | 23 (61) | 5 (12) |
*
p-Value: Fisher’s exact test or Wilcoxon rank-sum test for differences in variables between mutation groups.
CLL, chronic lymphocytic leukemia; IGHV, immunoglobulin heavy chain variable region; JHU, Johns Hopkins University; FISH, fluorescence in situ hybridization.