Table 4. Published multivariate analyses of neutrophil-to-lymphocyte ratio in malignant mesothelioma.
| Kao et al (2010) | Kao et al (2011) | Pinato et al (2012) | Kao et al (2013) | Meniawy et al (this study) | |
|---|---|---|---|---|---|
| Total no. of study patients | 173 | 85 | 171 | 148 | 274 |
| No. in multivariate model | NR | NR | NR | 130 | 274 |
| No. with NLR available |
168 (97%) |
84 (99%) |
159 (94%) |
79 (53%) |
274 (100%) |
| Chemotherapy | Extrapleural | Chemotherapy (41%) | Chemotherapy (53%) | Chemotherapy (62%) | |
| Treatments received | First line (69%) | pneumonectomy | Supportive care (42%) | Radiotherapy (34%) | Supportive care (38%) |
| |
Second line (31%) |
(EPP) |
Unknown (17%) |
EPP (5%) |
EPP (1%) |
| Median baseline NLR | NR | 3 | NR | 3.5 | 3.5 |
| Cutoff used in analysis |
<5 vs ⩾5 |
<3 vs ⩾3 |
<5 vs ⩾5 |
<3 vs ⩾3 |
<5 vs ⩾5 |
|
Prognostic variables entered into final multivariate model | |||||
| Age | NS | NS | + | ||
| Gender | NS | NS | NS | NS | NS |
| Nonepithelioid histology | + | NS | NS | + | + |
| Sarcomatous histology | + | ||||
| Stage | + | NS | |||
| Performance status | NS | + | |||
| Weight loss | + | ||||
| Chest pain | + | ||||
| Hb level | + | NS | |||
| White cell count | NS | NS | NS | NS | |
| Platelet count | NS | NS | + | ||
| Baseline NLR | + | + | + | + | NS |
| Calretinin score | + | ||||
| mGPS | + | ||||
| Albumin, EPS, CRP, PLR | NS | ||||
| Treatments received | NS | + | |||
Abbreviations: CRP=C-reactive protein; EPS=european organization for the research and treatment of cancer prognostic score; Hb=haemoglobin; mGPS=modified glasgow prognostic score; NLR=neutrophil-to-lymphocyte ratio; NR=not reported; NS=nonsignificant; PLR=platelet-to-lymphocyte ratio; +=significant (P<0.05).