Table 1. The results of univariate and multivariate analyses.

		Whole population				Male				Female
		Univariate		Multivariate		Univariate		Multivariate		Univariate		Multivariate
		HR	P-value	HR (95% CI)	P-value	HR	P-value	HR (95% CI)	P-value	HR	P-value	HR (95% CI)	P-value
Age	Continuous	1.034	0.012			1.034	0.040			1.033	0.193
Gender	M vs F	1.404	0.242
Presentation	Incidental vs symptomatic	4.241	<0.001			4.597	<0.001			3.211	0.020
Tumour size	Continuous	1.259	<0.001			1.299	<0.001			1.198	0.001
pT stage	1 vs 2 vs 3 vs 4	3.285	<0.001	2.261 (1.652–3.096)	<0.001	3.485	<0.001	2.418 (1.644–3.556)	<0.001	2.560	0.001	2.718 (1.342–5.507)	0.005
pN stage	0 or x vs positive	9.885	<0.001			9.783	<0.001			8.894	0.004
M stage	No vs yes	26.431	<0.001	8.037 (3.729–17.325)	<0.001	25.113	<0.001	11.100 (5.100–24.161)	<0.001	26.694	<0.001	23.767 (5.288–106.819)	<0.001
Nephrectomy	Partial vs total	7.331	0.005			565543.080	0.001			1.644	0.605
Nuclear grade	⩽2 vs ⩾3	12.066	<0.001	5.051 (2.601–9.808)	<0.001	14.830	<0.001	6.687 (2.929–15.265)	<0.001	8.039	<0.001	5.162 (1.445–18.437)	0.012
MVI	No vs yes	6.005	<0.001			6.415	<0.001			4.648	0.002
ECOG-PS	0 vs ⩾1	14.046	<0.001	2.911 (1.432–5.917)	<0.001	13.408	<0.001			14.082	<0.001	10.908 (3.327–35.762)	<0.001
CRP (mg dl–1)	<0.3 vs ⩾0.3	5.743	<0.001			6.323	<0.001			4.301	<0.001
BMI	Continuous	0.888	0.021			0.822	0.004	0.804 (0.677–0.955)	0.013	1.028	0.725

Abbreviations: BMI-body mass index; CI=confidence interval; CRP, C-reactive protein; ECOG-PS=Eastern Cooperative Oncology Group Performance Status; F=female; HR=Hazard ratio; M=male; MVI=microscopic venous invasion.