Table 2. Treatment-related toxicity according to CTCAE v3.0 (n=21).
| |
Grade 1 or 2 |
Grade 3 or 4 |
||
|---|---|---|---|---|
| Adverse event | No | Frequency (%) | No | Frequency (%) |
|
Nonhematologic | ||||
| Pain | 12 | 57 | 3 | 14 |
| Anorexia | 11 | 52 | 1 | 5 |
| Fatigue | 11 | 52 | 4 | 19 |
| Constipation | 9 | 43 | 0 | 0 |
| Rash | 8 | 38 | 0 | 0 |
| Depression | 6 | 29 | 0 | 0 |
| Oedema | 6 | 29 | 0 | 0 |
| Mucositis | 6 | 29 | 0 | 0 |
| Weight loss | 6 | 29 | 0 | 0 |
| Neuropathy | 5 | 24 | 1 | 5 |
| Nausea | 3 | 14 | 1 | 5 |
| Dehydration | 2 | 10 | 1 | 5 |
| Pneumonia | 1 | 5 | 3 | 14 |
| Urinary tract infection | 0 | 0 | 1 | 5 |
| TIA | 0 | 0 | 1 | 5 |
| DVT | 0 | 0 | 1 | 5 |
| Stroke |
0 |
0 |
1 |
5 |
|
Laboratory abnormalities | ||||
| Elevated triglycerides | 11 | 52 | 1 | 5 |
| Hyperglycaemia | 11 | 52 | 5 | 24 |
| Hypoalbuminemia | 10 | 48 | 0 | 0 |
| Hypocalcemia | 8 | 38 | 1 | 5 |
| High cholesterol | 8 | 38 | 1 | 5 |
| AST elevation | 6 | 29 | 1 | 5 |
| Elevated alk phos | 5 | 24 | 1 | 5 |
| Hypokalemia | 5 | 24 | 0 | 0 |
| Elevated creatinine | 5 | 24 | 1 | 5 |
| Hyponatremia | 4 | 19 | 1 | 5 |
| ALT elevation | 2 | 10 | 0 | 0 |
| Hypophosphatemia |
2 |
10 |
3 |
14 |
|
Haematologic | ||||
| Leucopenia | 16 | 76 | 0 | 0 |
| Anaemia | 13 | 62 | 3 | 14 |
| Thrombocytopenia | 9 | 43 | 7 | 33 |
| Lymphopenia | 8 | 38 | 5 | 24 |
Abbreviations: Alk Phos=alkaline phosphatase; ALT=alanine aminotransferase; AST=aspartate aminotransferase; DVT=deep vein thrombosis; TIA=transient ischaemic attack.