Table 2. Treatment-related toxicity according to CTCAE v3.0 (n=21).
|
Grade 1 or 2 |
Grade 3 or 4 |
||
---|---|---|---|---|
Adverse event | No | Frequency (%) | No | Frequency (%) |
Nonhematologic | ||||
Pain | 12 | 57 | 3 | 14 |
Anorexia | 11 | 52 | 1 | 5 |
Fatigue | 11 | 52 | 4 | 19 |
Constipation | 9 | 43 | 0 | 0 |
Rash | 8 | 38 | 0 | 0 |
Depression | 6 | 29 | 0 | 0 |
Oedema | 6 | 29 | 0 | 0 |
Mucositis | 6 | 29 | 0 | 0 |
Weight loss | 6 | 29 | 0 | 0 |
Neuropathy | 5 | 24 | 1 | 5 |
Nausea | 3 | 14 | 1 | 5 |
Dehydration | 2 | 10 | 1 | 5 |
Pneumonia | 1 | 5 | 3 | 14 |
Urinary tract infection | 0 | 0 | 1 | 5 |
TIA | 0 | 0 | 1 | 5 |
DVT | 0 | 0 | 1 | 5 |
Stroke |
0 |
0 |
1 |
5 |
Laboratory abnormalities | ||||
Elevated triglycerides | 11 | 52 | 1 | 5 |
Hyperglycaemia | 11 | 52 | 5 | 24 |
Hypoalbuminemia | 10 | 48 | 0 | 0 |
Hypocalcemia | 8 | 38 | 1 | 5 |
High cholesterol | 8 | 38 | 1 | 5 |
AST elevation | 6 | 29 | 1 | 5 |
Elevated alk phos | 5 | 24 | 1 | 5 |
Hypokalemia | 5 | 24 | 0 | 0 |
Elevated creatinine | 5 | 24 | 1 | 5 |
Hyponatremia | 4 | 19 | 1 | 5 |
ALT elevation | 2 | 10 | 0 | 0 |
Hypophosphatemia |
2 |
10 |
3 |
14 |
Haematologic | ||||
Leucopenia | 16 | 76 | 0 | 0 |
Anaemia | 13 | 62 | 3 | 14 |
Thrombocytopenia | 9 | 43 | 7 | 33 |
Lymphopenia | 8 | 38 | 5 | 24 |
Abbreviations: Alk Phos=alkaline phosphatase; ALT=alanine aminotransferase; AST=aspartate aminotransferase; DVT=deep vein thrombosis; TIA=transient ischaemic attack.