Table 2. Mortality, MRR, and interaction contrasts for CRC patients compared with persons in a matched population-based comparison cohort, overall and by CCI score.
| CCI score | Cohort | No. of persons | No. of deaths | Person-years | Standardised mortality rates per 1000 person-years (95% CI) | Adjusted MRRsa (95% CI) | Interaction contrast (95% CI) | Proportion of the mortality explained by interaction | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0–1 Year of follow-up | ||||||||||
| All | CRC | 56 963 | 17 089 | 45 559 | 400 | (394, 406) | 8.3 (8.1, 8.5) | NA | — | — |
| All | Comparison | 271 670 | 11 962 | 265 223 | 48 | (47, 48) | Ref. | NA | — | — |
| 0 | CRC | 34 918 | 8881 | 29 245 | 351 | (343, 359) | 15 (14, 15) | Ref. | — | — |
| 0 | Comparison | 172 041 | 3652 | 170 008 | 27 | (26, 28) | Ref. | — | — | — |
| 1 | CRC | 9747 | 3254 | 7509 | 415 | (401, 430) | 7.4 (7.0, 7.7) | 39 | (22, 55) | 9.4% |
| 1 | Comparison | 47 139 | 2755 | 45 723 | 53 | (51, 55) | Ref. | — | — | — |
| 2–3 | CRC | 9522 | 3548 | 7035 | 489 | (447, 530) | 5.1 (4.9, 5.3) | 79 | (36, 121) | 16% |
| 2–3 | Comparison | 44 788 | 4234 | 42 521 | 86 | (83, 89) | Ref. | — | — | — |
| 4+ | CRC | 2776 | 1406 | 1771 | 761 | (715, 807) | 3.9 (3.7, 4.3) | 262 | (215, 310) | 34% |
| 4+ |
Comparison |
7702 |
1321 |
6971 |
175 |
(165, 185) |
Ref. |
— |
— |
— |
|
Two to 5 years of follow-up | ||||||||||
| All | CRC | 39 862 | 14 274 | 102 813 | 143 | (141, 146) | 3.0 (2.9, 3.0) | NA | — | — |
| All | Comparison | 258 729 | 40 310 | 808 019 | 50 | (49, 50) | Ref. | NA | — | — |
| 0 | CRC | 26 029 | 8606 | 69 909 | 131 | (128 134) | 4.2 (4.1, 4.3) | Ref. | — | — |
| 0 | Comparison | 167 766 | 17 549 | 549 904 | 36 | (36, 37) | Ref. | — | — | — |
| 1 | CRC | 6490 | 2482 | 16 193 | 146 | (140, 152) | 2.3 (2.2, 2.4) | −9.8 | (−17, −3.1) | NA |
| 1 | Comparison | 44 215 | 9585 | 131 313 | 61 | (60, 62) | Ref. | — | — | — |
| 2–3 | CRC | 5973 | 2491 | 13 917 | 172 | (165, 179) | 2.0 (1.9, 2.0) | −3.0 | (−11, 4.9) | NA |
| 2–3 | Comparison | 40 390 | 10 902 | 111 329 | 80 | (79, 82) | Ref. | — | — | — |
| 4+ | CRC | 1370 | 695 | 2793 | 261 | (231, 290) | 1.7 (1.6, 1.8) | 37 | (7.0, 68) | 14% |
| 4+ | Comparison | 6358 | 2274 | 15 473 | 129 | (123, 134) | Ref. | — | — | — |
Abbreviations: CCI=Charlson Comorbidity Index; CI=confidence interval; CRC=colorectal cancer; MRR=mortality rate ratios; NA=not applicable; Ref.=reference.
a
Adjusted for age, gender, and CRC/index year. For the overall analysis, we also adjusted for CCI scores.