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. 2013 Sep 3;23(10):1215–1228. doi: 10.1038/cr.2013.124

Figure 7.

Figure 7

DNA-binding activity of FAAP24 is required for ATR-mediated checkpoint activation in response to ICL damage. (A) Ser317 phosphorylation of Chk1 in FAAP24−/− cells stably complemented with wild-type or mutant FAAP24. Cells were mock-treated (Ctrl) or treated with 150 ng/ml MMC for 6 h. Chk1 and β-actin serve as loading controls. (B) Clonogenic survival of FAAP24−/− cells stably complemented with wild-type or mutant FAAP24. Error bars represent SD from four independent experiments with triplicated plates.