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. Author manuscript; available in PMC: 2014 Oct 4.
Published in final edited form as: Toxicology. 2013 Jul 31;0:48–55. doi: 10.1016/j.tox.2013.07.015

Figure 3.

Figure 3

Exposure of mice to 30 mg/kg DE-71 for 30 days show an alteration in the expression of pre- and postsynaptic GABAergic proteins in the frontal cortex. (A) Treatment with DE-71 significantly reduced cortical GABA(A) 2α receptor subunit expression compared with untreated mice. (B) Similarly, DE-71 treatment resulted in a significant reduction in cortical GAD67 expression compared with untreated animals. (C) In contrast, DE-71 caused an increase in cortical vGAT expression, relative to untreated mice. (D) Expression of GAT1 in the cortex was unchanged following DE-71 treatments. (E) Representative immunoblots for each protein examined. Data represent mean ± SEM (4-6 animals per treatment group). **Values for animals that are significantly different from controls (p < 0.01). ***Values for animals significantly different from controls (p < 0.001).