Table III. Binding affinities of newly identified BAG3 interacting proteins.
Interacting proteins | ka (M−1 s−1)a | kd (s−1)b | KD (M) (kd/ka)c |
---|---|---|---|
14-3–3ζ | (1.4 ± 0.4) × 106 | (7.1 ± 3.3) × 10−2 | (5.1 ± 2.2) × 10−8 |
ATG3 | (4.2 ± 2.2) × 103 | (7.2 ± 1.8) × 10−4 | (1.7 ± 2.4) × 10−7 |
PSMB1 | (3.8 ± 1.7) × 103 | (4.6 ± 0.6) × 10−3 | (1.2 ± 0.8) × 10−6 |
HSP70 | (3.2 ± 1.5) × 104 | (5.3 ± 2.1) × 10−4 | (1.7 ± 1.3) × 10−8 |
MAPK7 | (7.3 ± 3.4) × 104 | (8.1 ± 1.5) × 10−2 | (1.1 ± 1.6) × 10−6 |
HSF1 | (9.6 ± 2.5) × 104 | (3.3 ± 1.2) × 10−3 | (3.4 ± 1.8) × 10−8 |
ENO1 | NDd | NDd | NDd |
a ka: association rate.
b kd: dissociation rate.
c KD: kd/ka, dissociation constant.
d ND, not determined because of a low interaction signal.