Table 2.

Multivariate associations with 25% estimated glomerular filtration rate decline.

	Hazard ratio	95% CI
TDF vs. NRTI use	1.04	0.68–1.59
Age >45 years	2.31	1.44–3.69
Race (black)	1.52	0.85–2.72
CD4 cell count <200 cells/μl (baseline)	2.66	1.65–4.29
Hypertension	1.56	1.00–2.45
PI/r	2.14	1.37–3.34

CI, confidence interval; NRTI, nucleoside reverse transcriptase inhibitor; PI/r, ritonavir-boosted protease inhibitor; TDF, tenofovir disoproxil fumarate.