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. 2013 Aug 16;122(14):2346–2357. doi: 10.1182/blood-2013-03-487801

Figure 7.

Figure 7

Effect (mean + SEM) of ovx on the SC expression of mRNA of genes known to be up-regulated by Wnt signaling. BM harvested at death was cultured for 1 week. SCs were purified, and mRNA levels were determined by real-time reverse transcription-polymerase chain reaction. SCs were obtained from (A) WT mice, (B) TCRβKO mice, (C) TCRβKO mice previously subjected to adoptive transfer of WT T cells, (D) CD40L−/− mice, (E) TCRβ−/− mice previously reconstituted with CD40L−/− T cells, (F) Wnt10b−/− mice, and (G) TCRβKO mice previously subjected to adoptive transfer of Wnt10b−/− T cells. The Wnt-dependent genes analyzed were aryl-hydrocarbon receptor (Ahr), axin2, cystein-rich protein 61 (Cyr61), naked cuticle 2 homolog (Nkd2), transgelin (tagln), transforming growth factor β 3 (TGFβ3), thrombospondin 1 (Thbs1), Twist gene homolog 1 (Twst1), and Wnt1 inducible signaling pathway protein 1 (Wisp1). n = 5 mice per group. *P < .05 compared with the corresponding sham-operated group.