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(A) Sequential diagram of our proposed signaling pathway. Activated IGF-1R binds to the Gα subunit of the heterotrimeric G protein complex. AGS3 binds and stabilizes GDP-bound Gα. Free Gβγ triggers the release of Tctex-1 from the dynein complex, enabling subsequent phosphorylation of Tctex-1. (B) Spatial diagram of our working model. BB: basal body.
