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. Author manuscript; available in PMC: 2013 Oct 4.
Published in final edited form as: Arch Pediatr Adolesc Med. 2012 Aug;166(8):738–744. doi: 10.1001/archpediatrics.2012.490

Table 2.

Comparison of Test Performance in Derivation and Validation Cohorts

Test Performance Prior Derivation Study
(internal validation)18
(N = 176)		 Multi-center Validation
(N = 2390)
Sensitivity 98.1% [88.8 – 99.9%] 95.5% [93.9 – 96.7%]
Specificity 32.0% [24.0 – 41.1%] 36.3% [33.9 – 38.9%]
Negative Predictive Value 97.5% [85.3 – 99.9%] 92.7% [90.1 – 94.6%]
Positive Predictive Value 39.0% [30.8 – 47.7%] 48.8% [46.5 – 51.1%]
Likelihood Ratio of Negative Test 0.06 [0.01 – 0.41] 0.12 [.09 – .17]

All values reported with 95% confidence interval