Scheme 3.
Synthesis of the aldehyde 6. Reagents and conditions: (a) bromoacetaldehyde dimethyl acetal (1.4 equiv), K2CO3 (6 equiv), DMF, 150 °C, 16 h, 97%; (b) Amberlyst-15 resin (10 mol %), MeCN:water (5:1), 85 °C, 20 h, 88%.
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