Size control of tissue development. (A) Small starting tissue for numerical simulations of the temporal-spatial dynamics model contains 64 cells in total. Stem cells are labeled in red, progenitor cells are in blue, and differentiated cells are in white. (B) One example tissue achieved homeostatic size control. This steady state tissue contains 15 stem cells, 1 progenitor cell and 158 differentiated cells. (C) Dynamics of cell numbers during tissue development. The red curve indicates the change of stem cell numbers, the blue line is for progenitor cells, and the black line is differentiated cells. Error bars show the standard deviations calculated from four simulation results at 100, 200, 300, 400, 500, and 600 time steps, respectively.