Figure 1. CO-OCS and SO-OCS reduced cell viability and induced mortality in breast cancer cell lines but not in normal ones.

Cells are treated with various concentrations of CO-OCS and SO-OCS (0–100 µM) for 72-h. A, Structures of the sp²-iminosugar-type S-octyl and C-octyl 2-oxa-3-oxocastanospermine glycosides SO-OCS and CO-OCS, respectively, evaluated in this work. Inhibitory effects of CO-OCS and SO-OCS on MCF-7 (B) and MDA-MB-231 cells (C). Results were expressed as percentage of the controls, which were arbitrarily assigned 100% viability. CO-OCS and SO-OCS increased cell mortality in MCF-7 (D) and MDA-MB-231 cells (E). Neither CO-OCS nor SO-OCS affects the cell viability (F) and the mortality (G) of MCF 10-A cells. The values indicated are mean ± SD of three independent experiments and analyses by ANOVA test ^* p<0.05, **p<0.01, ***p<0.001. compared with control group