Table 1. Top functional annotation terms of the 60 differentially expressed genes.
Terms | Ratio (%) | P value | Benjamini | Genes | |
---|---|---|---|---|---|
Overexpressed (n=26) | GO:0031224 ~ intrinsic to membrane | 50.0 | 0.010 | 0.363 | TMEM95, NRP1, SCN3A, PCDH19, FAM57B, NTRK3, SSTR3, UCP3, GIPR, DPEP3, TMTC3, IGSF9, GPR12 |
GO:0030516 ~ regulation of axon extension | 7.7 | 0.023 | 0.995 | NTRK3, NRP1 | |
GO:0016021 ~ integral to membrane | 46.2 | 0.025 | 0.454 | NTRK3, NRP1, TMEM95, SSTR3, UCP3, SCN3A, GIPR, TMTC3, IGSF9, PCDH19, GPR12, FAM57B | |
GO:0019932 ~ second-messenger-mediated signaling | 11.5 | 0.031 | 0.971 | SSTR3, GIPR, HIST1H4E | |
GO:0016358 ~ dendrite development | 7.7 | 0.041 | 0.957 | NRP1, IGSF9 | |
Underexpressed (n=34) | GO:0034728 ~ nucleosome organization | 8.8 | 0.006 | 0.371 | SET, NAP1L1, HIST1H3I |
GO:0006325 ~ chromatin organization | 11.8 | 0.011 | 0.388 | SET, MORF4, NAP1L1, HIST1H3I | |
GO:0006350 ~ transcription | 20.6 | 0.037 | 0.729 | SCRT2, NACC1, PTGER3, MORF4, FOXC2, NFE2L1, SOX8 | |
GO:0065003 ~ macromolecular complex assembly | 11.8 | 0.048 | 0.784 | NACC1, SET, NAP1L1, HIST1H3I | |
GO:0008009 ~ chemokine activity | 5.9 | 0.055 | 0.935 | CXCL5, CKLF |
Bold font indicates cancer-related genes according to the Ingenuity knowledge database.