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. 2013 Oct 4;8(10):e77165. doi: 10.1371/journal.pone.0077165

Figure 2. Temporal trends in the frequencies of fim3, ptxP, ptxA, and prn alleles within Bordetella pertussis isolates in Japan from 2002 to 2012. Four allelic genes, fim3 (A), ptxP (B), ptxA (C), and prn (D), of 134 B. pertussis isolates were sequenced.

Figure 2

Isolate allele frequencies are shown by time period: 2002−2004 (non-epidemic, n = 23), 2005−2007 (pre-epidemic, n = 39), 2008−2010 (epidemic, n = 33), and 2011−2012 (post-epidemic, n = 39). The regression line shows the relationship between the frequency of virulence-associated allelic variant (fim3B, ptxP3, ptxA1, or prn2) and the 4 time periods.