Table 4. Relationships between mean diffusivity and age in SZ and HC subjects.
| ROI | Side | HC | SZ | ||||||
| r | plin | m | MD0 | r | plin | m | MD0 | ||
| Frontal lobe | |||||||||
| Frontal operculum cortex | L | 0.38 | 0.001 | 3.56 | 747.4 | 0.43 | <0.001 | 6.00 | 774.2 |
| Frontal pole | L | 0.48 | <0.001 | 6.43 | 806.3 | 0.37 | 0.002 | 4.92 | 881.5 |
| R | 0.54 | <0.001 | 6.67 | 772.1 | 0.42 | <0.001 | 4.99 | 856.4 | |
| Inferior frontal gyrus, pars opercularis | L | 0.57 | <0.001 | 8.01 | 824.8 | 0.35 | 0.003 | 5.56 | 983.8 |
| R | 0.60 | <0.001 | 8.65 | 769.0 | 0.40 | <0.001 | 5.96 | 919.5 | |
| Middle frontal gyrus | L | 0.57 | <0.001 | 9.05 | 758.1 | 0.44 | <0.001 | 5.91 | 885.6 |
| R | 0.55 | <0.001 | 8.70 | 785.0 | 0.38 | 0.001 | 4.78 | 964.4 | |
| Superior frontal gyrus | L | 0.58 | <0.001 | 13.6 | 852.0 | 0.34 | 0.004 | 6.91 | 1077.9 |
| R | 0.54 | <0.001 | 13.0 | 854.4 | 0.37 | 0.002 | 7.14 | 1084.0 | |
| Temporal lobe | |||||||||
| Planum polare | L | 0.36 | 0.002 | 6.97 | 853.3 | 0.40 | <0.001 | 12.03 | 793.4 |
| Superior temporal gyrus, anterior division | R | 0.40 | <0.001 | 4.57 | 817.9 | 0.38 | 0.001 | 4.41 | 837.2 |
| Temporal pole | R | 0.46 | <0.001 | 4.82 | 815.8 | 0.36 | 0.002 | 5.62 | 858.4 |
| Insula | |||||||||
| Insular cortex | L | 0.39 | <0.001 | 3.09 | 944.3 | 0.27 | 0.02 | 3.91 | 1027.6 |
| Parietal lobe | |||||||||
| Precentral gyrus | L | 0.54 | <0.001 | 8.05 | 876.3 | 0.35 | 0.003 | 4.26 | 1015.7 |
| Occipital lobe | |||||||||
| Intracalcarine cortex | R | 0.53 | <0.001 | 3.40 | 822.6 | 0.37 | 0.002 | 2.53 | 917.1 |
The significance threshold, plin, was chosen as a function of the number of ROIs in each lobe. Frontal lobe: plin<0.05/12; Temporal lobe: plin<0.05/16; Insula: plin<0.05; Parietal lobe: plin<0.05/12; Occipital lobe: plin<0.05/7. L = left; R = right; r = Pearson’s correlation coefficient; m = regression angular coefficient; MD0 = regression intercept; HC = Healthy Controls; SZ = Schizophrenia; ROI = Region of Interest; MD = Mean Diffusivity.