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. 2013 Oct 4;8(10):e75404. doi: 10.1371/journal.pone.0075404

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© 2013 Cordero-Maldonado et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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After exposing the larvae to mechanical and biological damages, anti-inflammatory drugs and non anti-inflammatory compounds were evaluated for their activity in the LPS-enhanced leukocyte migration assay. Migrating MPO-positive cells were counted in the tail tip and the results expressed as relative leukocyte migration (RLM) values. Results for NSAIDs (upper panel) and SAIDs (middle panel) show a significant inhibition of leukocytes migration in a concentration-dependent manner while non anti-inflammatory drugs (lower panel) indicate no significant effect on leukocyte migration. In each case, values are plotted as RLM (SEM, n = 3 replicates with 10 larvae each) and a value of 0.5 was established as a cut-off for anti-inflammatory activity. ***p<0.001, **0.001<p<0.01, *0.01<p<0.05.