Table 4. Relationship between cut-off inhibition index and in vitro efficacy rate by means of HDRA.

Chemotheraputic agents and SULF2 methylation	Cut-off inhibition rate
	30%				40%				50%				60%
	Sensitive (sample number)	Resistant (sample number)	Efficacy rate (%)	P value	Sensitive (sample number)	Resistant (sample number)	Efficacy rate (%)	P value	Sensitive (sample number)	Resistant (sample number)	Efficacy rate (%)	P value	Sensitive (sample number)	Resistant (sample number)	Efficacy rate (%)	P value
Cisplatin (20 ug/ml)
SULF2M	16	12	57.14	0.02	12	16	42.86	0.07	11	17	39.29	0.26	6	22	27.27	0.46
SULF2U	58	14	80.56		46	26	63.89		39	33	54.17		22	50	44.00
Irinotecan (20 ug/ml)
SULF2M	25	3	89.29	0.01	21	7	75.00	0.07	16	12	57.14	0.11	12	16	42.86	0.05
SULF2U	45	27	62.50		38	34	52.78		27	45	37.50		16	56	22.22