Table 6. Univariate and multivariate Cox proportional hazard analysis of factors associated with overall survival.

Variables	Univariate			Multivariate
	No.	HR (95% CI)	P	HR (95% CI)	P
Age, y
>62	26	1(ref.)		1(ref.)
≦62	30	0.632 (0.304–1.314)	0.21	0.509 (0.223–1.165)	0.11
Sex
Male	42	1(ref.)		1(ref.)
Female	14	0.809 (0.296–1.788)	0.49	0.363 (0.124–1.066)	0.07
Histology
Adenocarcinoma	43	1(ref.)		1(ref.)
Mucinous	7	0.849 (0.292–2.467)	0.76	0.206 (0.052–0.818)	0.03
Signet ring cell	6	1.116 (0.333–3.737)	0.86	0.568 (0.131–2.460)	0.45
Tumor Site
Distal stomach	15	1(ref.)		1(ref.)
Proximal stomach	24	1.813 (0.626–5.248)	0.27	3.381 (0.794–14.395)	0.10
Whole stomach	17	3.975 (1.390–11.363)	0.01	8.105 (1.814–36.218)	0.01
Stage
I, II	18	1(ref.)		1(ref.)
III, IV	38	1.716 (0.729–4.040)	0.22	2.321 (0.487–11.050)	0.29
Histological grade
2	11	1(ref.)		1(ref.)
3	28	2.810 (0.820–9.631)	0.10	6.354 (1.134–35.601)	0.05
Mixed 2–3	17	2.287 (0.619–8.456)	0.22	4.401 (0.891–21.751)	0.07
Lymph node metastasis
No	11	1(ref.)		1(ref.)
Yes	45	1.732 (0.601–4.988)	0.31	1.018 (0.216–4.791)	0.98
SULF2
Methylation	19	1(ref.)		1(ref.)
Unmethylation	37	0.413 (0.197–0.866)	0.02	0.525 (0.215–1.280)	0.04

In this multivariate analysis, age, sex, tumor site, stage, histological grade, lymph node metastasis and SULF2 methylation were included.