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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Biomaterials. 2013 Sep 7;34(37):9331–9340. doi: 10.1016/j.biomaterials.2013.08.016

Figure 5. MMP inhibition prevents EC organization in PEG-collagen hydrogels.

Figure 5

A) EC invasion and organization were inhibited by addition of 5 μM GM6001 in the PC+0%PEG and PC+1%PEG materials. EC survival in the PC+2%PEG condition was limited. Red staining is for CD31+ cells. B) Quantification of network morphology revealed significant increases in total network lengths in the presence of low dose GM6001 (1 μM) in PC+0%PEG and PC+1%PEG owing to a larger number of EC structures. Higher doses (5 μM) significantly reduced network lengths in PC+0%PEG. Both doses reduced total network lengths in collagen gel controls. C) Quantification of mean segment lengths showed reductions in PC+0%PEG and PC+1%PEG gels with both doses of inhibitor. Matched symbols denote statistical significance (P < 0.01).