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. 2013 Sep 23;8:3573–3585. doi: 10.2147/IJN.S47745

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© 2013 Lipka et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed.

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The influence of the external buffer on the encapsulation efficiency (EE) of EPI in HSPC/Chol/DSPE-PEG 2000 LUVs containing 300 mM ascorbic acid (♦) or 300 mM ammonium ascorbate (▲) after 5 minutes of incubation.

Abbreviations: EPI, epirubicin; HSPC/Chol/DSPE-PEG 2000, hydrogenated soy phosphatidylcholine/cholesterol/1,2-distearoyl-sn-glycero-phosphoethanolamine-N-(poly[ethylene glycol]2000); LUVs, large unilamellar vesicles.