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. 2013 Sep 23;8:3573–3585. doi: 10.2147/IJN.S47745

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© 2013 Lipka et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed.

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Comparison of the release of EPI in 50% human plasma from the HSPC/Chol/DSPE-PEG 2000 (5.5:4:0.5 mol/mol) liposomes into which it had been encapsulated using different ion and/or pH gradients: 300 mM ammonium ascorbate at pH 4.0 (♦), 300 mM ascorbic acid at pH 2.4 (O), 300 mM ammonium sulfate at ph 5.5 (▲), and 300 mM citrate buffer at pH 4.0 (■).

Abbreviations: EPI, epirubicin; HSPC/Chol/DSPE-PEG 2000, hydrogenated soy phosphatidylcholine/cholesterol/1,2-distearoyl-sn-glycero-phosphoethanolamine-N-(poly[ethylene glycol]2000).