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. 2013 Sep 23;8:3573–3585. doi: 10.2147/IJN.S47745

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© 2013 Lipka et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed.

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(A–D) Comparison of cytotoxicity of EPI encapsulated in HSPC/Chol/DSPE-PEG 2000 (5.5:4:0.5 mol/mol) liposomes using an ascorbic acid gradient (EPI lip ascorbic acid pH 2.4), ammonium ascorbate gradient (EPI lip ascorbic acid pH 4.0) or ammonium sulfate gradient (EPI am sulfate) and that of free EPI (EPI free). The cytotoxicity was measured on MCF-7 cells after 48 (A) and 72 hours (B), and on 4T-1 cells after 48 (C) and 72 hours (D).

Abbreviations: EPI, epirubicin; HSPC/Chol/DSPE-PEG 2000, hydrogenated soy phosphatidylcholine/cholesterol/1,2-distearoyl-sn-glycero-phosphoethanolamine-N-(poly[ethylene glycol]2000).

(A–D) Comparison of cytotoxicity of EPI encapsulated in HSPC/Chol/DSPE-PEG 2000 (5.5:4:0.5 mol/mol) liposomes using an ascorbic acid gradient (EPI lip ascorbic acid pH 2.4), ammonium ascorbate gradient (EPI lip ascorbic acid pH 4.0) or ammonium sulfate gradient (EPI am sulfate) and that of free EPI (EPI free). The cytotoxicity was measured on MCF-7 cells after 48 (A) and 72 hours (B), and on 4T-1 cells after 48 (C) and 72 hours (D).

Abbreviations: EPI, epirubicin; HSPC/Chol/DSPE-PEG 2000, hydrogenated soy phosphatidylcholine/cholesterol/1,2-distearoyl-sn-glycero-phosphoethanolamine-N-(poly[ethylene glycol]2000).