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Effects of EPI (free or in liposomal formulation) given at a dose of 6 mg/kg in the 4T-1 murine mammary cancer model. Control, saline-injected mice (■), free EPI (♦), EPI encapsulated in liposomes using ascorbic acid gradient (•), and EPI encapsulated in liposomes using ammonium ascorbate gradient (Δ).
Abbreviation: EPI, epirubicin.
