Table 2.

Summary of the pharmacokinetic parameters of the free and liposomal EPI

Sample	AUC0–24 (μmol/hour/mL)	AUMC (μmol/hour/mL)	MRT (hours)	t½ (hours)	Clb (mL/kg/hour)
Free EPI	0.009745	0.085920	8.816941	6.111438	3540.322526
HSPC/Chol/DSPE-PEG 2000 5.5:4:0.5	14.1791	395.871	27.9193	18.6165	2.510540

Note: For the clarity of the presented data, standard deviations (<3%) are not shown.

Abbreviations: EPI, epirubicin; AUC, area under the curve; AUMC, area under the first moment curve; MRT, mean residence time; t_½, half-life; Clb, biliary clearance; HSPC/Chol/DSPE-PEG 2000, hydrogenated soy phosphatidylcholine/cholesterol/1,2-distearoyl-sn-glycero-phosphoethanolamine-N-(poly[ethylene glycol]2000).