Figure 7.

The effect of fasudil on ischemic lesion expansion and endothelial nitric oxide synthase (eNOS) dysfunction. (A) Systemic treatment of fasudil (10 mg/kg body weight) enhances eNOS phosphorylation in the normal brain cortex, which lasts up to 8 hours after injection. *P<0.05 versus control, n=6 in each group. (B) Fasudil injection immediately and 24 hours after ischemia ameliorates ischemic brain injury 48 hours after ischemia. *P<0.05 versus vehicle-treated group, n=9 in each group. (C, D) According to the reduction in brain tissue injury, eNOS phosphorylation and dimerization were significantly preserved upon fasudil treatment. Assays were performed 30 hours after ischemia. *P<0.05 versus vehicle-treated group, n=5 in each group.