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Aggregation and secretion in a participant with a homozygous P2Y12 mutation that prevents receptor expression. Aggregation and secretion in a participant (p) with a homozygous mutation in P2Y12 that introduces a frame-shift mutation early in the coding sequence (c.36delG, p.Gly12fs). Responses are shown alongside a control (c). The PRP platelet count in the control and participant were 4.1 × 108/mL and 3.9 × 108/mL, respectively.
